RESUMO
Background and Purpose: according to the studies that have been conducted so far, the corona virus has more severe clinical consequences in diabetic patients than in non-diabetic cases;Therefore, the present study was conducted with the aim of investigating the severity of the disease and mortality in patients infected with the Coronavirus between these 2 groups. Materials and Methods: In this cross-sectional-analytical study, the clinical records of 185 hospitalized patients with a positive laboratory diagnosis of Covid-19 were reviewed from February 14 to February 26, 2020. The patients were divided into 2 non-diabetic (95 people) and diabetic (90 people) groups, and their clinical symptoms and blood biochemical parameters were compared. Results: Based on the results, most of the patients were male and compared to non-diabetic patients, the diabetic group was significantly older (P=0.01). In this study, the disturbance in paraclinical factors such as d-dimer, BUN, VBG and lymphopenia in diabetic patients was significantly higher than in the control group, which indicates the need for more care in diabetic patients. Conclusion: it is suggested to follow health protocols for people with land diseases, be more careful., therefore, more extensive research with larger sample sizes is needed to achieve more accurate results. [ FROM AUTHOR] Copyright of Journal of Pharmaceutical Negative Results is the property of ResearchTrentz and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)
RESUMO
Recent investigations are seeking a novel treatment to control the new pandemic of coronavirus 19 (COVID-19). The aim of this systematic review was to study the effect of ozone therapy on COVID-19 patients and the available supporting evidence. Electronic databases including MEDLINE (via PubMed), EMBASE, Cochrane Library (CENTRAL), and TRIP, clinical trial registries, and preprint sources were searched for published evidence-based articles. In addition, manual searching was conducted for articles published up to April 6, 2020, using MeSH and free text keywords with no language limitation. Articles were screened, categorized, and extracted for relative data. Data were reported in a descriptive manner. Among 234 articles, 9 were selected for review of the inclusion criteria. No published original articles were found regarding the efficacy of ozone therapy on COVID-19. Five review studies were found in which the potential role of systemic ozone therapy was concluded to be effective in controlling COVID-19 because of its antiviral, oxygenation, anti-inflammatory, oxidation balancing, and immunomodulation effects. Three ongoing clinical trials were registered in China. A preliminary report of an ongoing study in Italy on 46 patients (11 intubated and 35 non-intubated) showed that in 39 (84%) of the patients, an improvement was seen. In spite of the promising background data, as well as the expert opinions and a preliminary report indicating the effectiveness of ozone, there is still not enough evidence to confirm this as a viable treatment option for COVID-19.